Chiefs rule Isiah Pacheco out for Sunday

Chiefs running back Isiah Pacheco has been ruled out for Sunday's game against the Buffalo Bills due to a knee injury that kept him out of practice all week. Head coach Andy Reid mentioned that the injury is not expected to be long-term. In Pacheco's absence, Kareem Hunt and Brashard Smith will handle running back duties for the Chiefs. Additionally, left tackle Josh Simmons will miss another game for personal reasons. His replacement, Jaylon Moore, who missed practice on Friday due to illness, is listed as questionable but is expected to play. Right guard Trey Smith, dealing with a back issue, is also questionable but participated in full practice and is anticipated to be in the lineup.